Visual MRI based targeting in DBS for movement disorders.A short introduction in how to identify the commonly used brain targets in stereotactic functional neurosurgery. Speaker Prof. Patric BlomstedtNeurosurgeon and professor at University of Umea, Sweden   Prof. Patric Blomstedt is neurosurgeon with a long history of neuromodulation for various movement disorders. He is professor at University of Umea, Sweden.  /wp-content/uploads/videos/wssfn23112022.mp4 Moderated by Dr Nico EnslinConsultant neurosurgeonRed Cross War Memorial Children’s Hospital and ConstantiabergUniversity of Cape Town, Cape Town, South Africa

Prof. Coubes and Dr. Poulen will discuss the work that they have been doing for more than 25 years on neuromodulation for secondary dystonia conditions and many of the “atypical” indications as well. A fascinating talk by one of the world’s leading experts in the field of DBS for movement disorders. Speakers Prof. Philippe Coubes, MD, PhDDepartment of Neurosurgery, Montpellier University hospitalDirector of the Research Unit on Movement and Behaviour DisordersMontpellier, France  Head of the multidisciplinary team “Intractable brain pathology” which currently manages adult and pediatric patients in two separated units. Montpellier’s group has developped the use of DBS in many diseases associated with dystono-dyskinetic syndromes and/or behavioural disorders. He has especially contributed to the validation of MRI-guided stereotactic surgery under general anesthesia without MER. Gaëtan Poulen, MD, PhDDepartment of Neurosurgery, Montpellier University hospitalMontpellier, France /wp-content/uploads/videos/wssfn30082022.mp4 Moderated by Dr Nico EnslinConsultant neurosurgeonRed Cross War Memorial Children’s Hospital and ConstantiabergUniversity of Cape Town, Cape Town, South Africa

Speakers Roberto Martinez, MD, PhDDepartment of Functional NeurosurgeryDepartment of Gamma Knife RadiosurgeryHospital Ruber InternationalMadrid, Spain. > Radiofrequency and Gamma Knife radiosurgery for aggressiveness associated with Autism Spectrum Disorder Jorge C Holguin Lew, MD, Mphil, PhDLecturer in Psychopathology CES UniversityCenter for neurostimulation in Psychiatry (CETNI)Medellín, Colombia > Conceptual, Clinical and neurobiological issues in aggression: a view from neuropsychiatry William D Hutchison, PhDProfessor, Dept.’s Surgery and Physiology, University of TorontoSenior Scientist, Clinical and Computational NeuroscienceKrembil Research Institute, Humboldt ScholarToronto Ontario, Canada > Intraoperative mapping with microelectrodes for posterior hypothalamic DBS in aggressiveness Flavia Venetucci Gouveia, MSc, PhDPostdoctoral Researcher at The Hospital for Sick ChildrenToronto, Ontario, Canada > Brain networks involved in symptom improvement following posterior hypothalamus deep brain stimulation for aggressive behaviour. /wp-content/uploads/videos/wssfn24052022.mp4 Moderated by Dr. A. RUSHNAClinical Instructor, Michigan State UniversityDirector of Restorative and Functional NeurosurgerySpectrum Health Medical GroupGrand Rapids, MI, USA

Speakers Clement Hamani, PhDSunnybrook Research InstituteCentre of Neuromodulation, Hurvitz Brain Science CenterToronto, ON, Canada > Neuroanatomy of surgery for aggressive behaviour. Cristina V Torres, MD, PhDDepartment of Neurosurgery, University Hospital La PrincesaHospital Ruber InternacionalMadrid, Spain > Intraoperative findings during hypothalamic DBS for aggressiveness. Adriana-Lucía Lopez-Ríos, MDDepartment of Neurosurgery, Hospital San VicenteFundación Medellín y RíonegroMedellín, Colombia > Deep brain Stimulation for aggressiveness. /wp-content/uploads/videos/wssfn22022022.mp4 Moderated by Dr. A. RUSHNAClinical Instructor, Michigan State UniversityDirector of Restorative and Functional NeurosurgerySpectrum Health Medical GroupGrand Rapids, MI, USA

Speakers Jin Woo Chang, MD, PhD Jin Woo Chang, MD, PhDWSSFN PresidentSouth Korea > Opening remarks Currently Dr. Chang serves as president of World Society for Stereotactic & Functional Neurosurgery (WSSFN) from 2019. In addition, he is also a section editor of World Neurosurgery and member of the editorial board for the official journal of WSSFN as well as the official journal of the International Neuromodulation Society (INS). Current position: Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea. Kendall H. Lee, MD, PhD Kendall H. Lee, MD, PhDWSSFN Scientific Committee ChairmanUSA > Welcome Kendall H Lee is Professor of Neurological Surgery and Biomedical Engineering at Mayo Clinic Rochester. He received his M.D. and Ph.D. degrees from Yale University in 1998. His doctoral dissertation was on neurochemical modulation of synchronized oscillations in the thalamus (Department of Neurobiology). He completed his neurosurgery residency at Dartmouth-Hitchcock Medical Center, with an emphasis on stereotactic and functional neurosurgery and deep brain stimulation (DBS). In 2006, He joined Mayo Clinic as a stereotactic and functional neurosurgeon with clinical emphasis on DBS. He founded and is a co-director of the Mayo Neural Engineering Laboratories (NEL) since 2006. His research focusses on neuroscience, specifically in electrophysiology, stereotactic and functional neurosurgery, and electrochemistry. For the past fifteen years, his research has focused on elucidating the therapeutic mechanisms of electrical stimulation in restoring function in both brain and spinal cord. His lab’s endeavors have included intensive collaboration with Mayo’s Division of Engineering to develop novel research devices such as wireless fast-scan cyclic voltammetry designed for use during human and animal DBS surgery to monitor the neurochemical and electrophysiological bases of DBS, as well as research tools and novel stereotactic headframes and MR imaging strategies to investigate effects. Russell Lonser, MD Russell Lonser, MDUSA Magnetic resonance imaging-guided gene therapy for thetreatment of aromatic L-aminoacid decarboxylase deficiency Mojgan Hodaie, MD, FRCSC Mojgan Hodaie, MD, FRCSCCanada Advanced structural brain imagingin functional neurosurgery Bradley J. Erikson, MD, PhD Bradley J. Erikson, MD, PhDUSA Deep Learning in Neurosurgery Shiro Horisawa, MD Shiro Horisawa, MDJapan Forel’s field surgery for movementdisorders and beyond Jin Woo Chang, MD, PhDWSSFN PresidentSouth Korea > Opening remarks Currently Dr. Chang serves as president of World Society for Stereotactic & Functional Neurosurgery (WSSFN) from 2019. In addition, he is also a section editor of World Neurosurgery and member of the editorial board for the official journal of WSSFN as well as the official journal of the International Neuromodulation Society (INS). Current position: Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea. Kendall H. Lee, MD, PhDWSSFN Scientific Committee ChairmanUSA > Welcome Kendall H Lee is Professor of Neurological Surgery and Biomedical Engineering at Mayo Clinic Rochester. He received his M.D. and Ph.D. degrees from Yale University in 1998. His doctoral dissertation was on neurochemical modulation of synchronized oscillations in the thalamus (Department of Neurobiology). He completed his neurosurgery residency at Dartmouth-Hitchcock Medical Center, with an emphasis on stereotactic and functional neurosurgery and deep brain stimulation (DBS). In 2006, He joined Mayo Clinic as a stereotactic and functional neurosurgeon with clinical emphasis on DBS. He founded and is a co-director of the Mayo Neural Engineering Laboratories (NEL) since 2006. His research focusses on neuroscience, specifically in electrophysiology, stereotactic and functional neurosurgery, and electrochemistry. For the past fifteen years, his research has focused on elucidating the therapeutic mechanisms of electrical stimulation in restoring function in both brain and spinal cord. His lab’s endeavors have included intensive collaboration with Mayo’s Division of Engineering to develop novel research devices such as wireless fast-scan cyclic voltammetry designed for use during human and animal DBS surgery to monitor the neurochemical and electrophysiological bases of DBS, as well as research tools and novel stereotactic headframes and MR imaging strategies to investigate effects. Russell Lonser, MDUSA Magnetic resonance imaging-guided gene therapy for thetreatment of aromatic L-aminoacid decarboxylase deficiency Mojgan Hodaie, MD, FRCSCCanada Advanced structural brain imagingin functional neurosurgery Bradley J. Erikson, MD, PhDUSA Deep Learning in Neurosurgery Shiro Horisawa, MDJapan Forel’s field surgery for movementdisorders and beyond /wp-content/uploads/videos/wssfn05112021.mp4 Moderated by Bomin Sun, MD, PhD Bomin Sun, MD, PhDChina Kendall H. Lee, MD, PhD Kendall H. Lee, MD, PhDWSSFN Scientific Committee ChairmanUSA Kendall H Lee is Professor of Neurological Surgery and Biomedical Engineering at Mayo Clinic Rochester. He received his M.D. and Ph.D. degrees from Yale University in 1998. His doctoral dissertation was on neurochemical modulation of synchronized oscillations in the thalamus (Department of Neurobiology). He completed his neurosurgery residency at Dartmouth-Hitchcock Medical Center, with an emphasis on stereotactic and functional neurosurgery and deep brain stimulation (DBS). In 2006, He joined Mayo Clinic as a stereotactic and functional neurosurgeon with clinical emphasis on DBS. He founded and is a co-director of the Mayo Neural Engineering Laboratories (NEL) since 2006. His research focusses on neuroscience, specifically in electrophysiology, stereotactic and functional neurosurgery, and electrochemistry. For the past fifteen years, his research has focused on elucidating the therapeutic mechanisms of electrical stimulation in restoring function in both brain and spinal cord. His lab’s endeavors have included intensive collaboration with Mayo’s Division of Engineering to develop novel research devices such as wireless fast-scan cyclic voltammetry designed for use during human and animal DBS surgery to monitor the neurochemical and electrophysiological bases of DBS, as well as research tools and novel stereotactic headframes and MR imaging strategies to investigate effects. Bomin Sun, MD, PhDChina Kendall H. Lee, MD, PhDWSSFN Scientific Committee ChairmanUSA Kendall H Lee is Professor of Neurological Surgery and Biomedical Engineering at Mayo Clinic Rochester. He received his M.D. and Ph.D. degrees from Yale University in 1998. His doctoral dissertation was on neurochemical modulation of synchronized oscillations in the thalamus (Department of Neurobiology). He completed his neurosurgery residency at Dartmouth-Hitchcock Medical Center, with an emphasis on stereotactic and functional neurosurgery and deep brain stimulation (DBS). In 2006, He joined Mayo Clinic as a stereotactic and functional neurosurgeon with clinical emphasis on DBS. He founded and is a co-director of the Mayo Neural Engineering Laboratories (NEL) since 2006. His research

Speaker Professor Marwan HarizEmeritus Professor and previous Head Of Division of Functional and stereotactic Neurosurgery at Queen’s Square Hospital in London. Professor Hariz currently joins Prof Patric Blomstedt in Sweden at Umea University’s Functional Neurosurgical Unit.Professor Hariz is a well known and well loved speaker and neurosurgeon all over the world. He is one of the renowned neurosurgeons and researchers in the field of stereotactic neurosurgery.He will talk about ethical issues pertaining to Deep Brain Stimulation as well as interesting Historical aspects of DBS. /wp-content/uploads/videos/wssfn03112021.mp4 Moderated by Dr Nico EnslinConsultant neurosurgeonRed Cross War Memorial Children’s Hospital and ConstantiabergUniversity of Cape Town, Cape Town, South Africa

This webinar will focus on patient selection, workup for surgery, target selection and surgical techniques and outcomes of lesioning techniques. All rounded off with the privilege to have an expert psychiatrist with a pro-neurosurgery viewpoint, give his opinion and discuss selection and outcomes. Speakers Keith Matthews, MD, PhDProfessor of PsychiatryDivision of Molecular and Clinical MedicineSchool of MedicineUniversity of DundeeDundee, United Kingdom Prof Ludvic ZrinzoQueen’s Square HospitalUniversity College of LondonLondon, United Kingdom /wp-content/uploads/videos/wssfn08072021.mp4 Moderated by Dr Nico EnslinConsultant neurosurgeonRed Cross War Memorial Children’s Hospital and ConstantiabergUniversity of Cape Town, Cape Town, South Africa

Speakers Jin Woo Chang, MD, PhD Jin Woo Chang, MD, PhDWSSFN President > Opening remarks Currently Dr. Chang serves as president of World Society for Stereotactic & Functional Neurosurgery (WSSFN) from 2019. In addition, he is also a section editor of World Neurosurgery and member of the editorial board for the official journal of WSSFN as well as the official journal of the International Neuromodulation Society (INS). Current position: Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea. Kendall H. Lee, MD, PhD Kendall H. Lee, MD, PhDWSSFN Scientific Committee Chairman > Welcome Kendall H Lee is Professor of Neurological Surgery and Biomedical Engineering at Mayo Clinic Rochester. He received his M.D. and Ph.D. degrees from Yale University in 1998. His doctoral dissertation was on neurochemical modulation of synchronized oscillations in the thalamus (Department of Neurobiology). He completed his neurosurgery residency at Dartmouth-Hitchcock Medical Center, with an emphasis on stereotactic and functional neurosurgery and deep brain stimulation (DBS). In 2006, He joined Mayo Clinic as a stereotactic and functional neurosurgeon with clinical emphasis on DBS. He founded and is a co-director of the Mayo Neural Engineering Laboratories (NEL) since 2006. His research focusses on neuroscience, specifically in electrophysiology, stereotactic and functional neurosurgery, and electrochemistry. For the past fifteen years, his research has focused on elucidating the therapeutic mechanisms of electrical stimulation in restoring function in both brain and spinal cord. His lab’s endeavors have included intensive collaboration with Mayo’s Division of Engineering to develop novel research devices such as wireless fast-scan cyclic voltammetry designed for use during human and animal DBS surgery to monitor the neurochemical and electrophysiological bases of DBS, as well as research tools and novel stereotactic headframes and MR imaging strategies to investigate effects. Nader Pouratian, MD, PhD Nader Pouratian, MD, PhD > Feasibility and Functional Outcomes of Human Visual Cortical Prostheses Dr Pouratian’s integrated clinical and research interests focus on using and developing novel neuromodulatory approaches to ameliorate neurological and psychiatric disease. His research specifically focuses on in-depth exploration of brain mapping signals (LFP, ECoG, DTI, fMRI) in order to characterize the network basis of disease and therapeutic neuromodulation, with a goal of creating novel stimulation-based therapies. Christian Lüscher, MD Christian Lüscher ,MD > Optical methods to observe and manipulate brain function Christian Lüscher did his medical school in Lausanne & Berne. Since 2000 he is the head a research group and clinical attending at the Medical Faculty of the University of Geneva. His work aims at understanding the neural mechanism underlying addiction and other behavioral diseases, for which he has received numerous distinctions (e.g. Otto Naegeli Prize 2020). Recently, he has proposed novel protocols for deep brain stimulation based on optogenetic circuit interrogation in rodent models of addiction and obsessive compulsive disorders. Michael Kaplitt, MD, PhD Michael Kaplitt, MD, PhD > Gene and Cell Therapy in Parkinson’s Disease Michael G. Kaplitt, MD PhD is Professor of Neurological Surgery with tenure, Residency Program Director and Vice-Chairman for Research in the Department of Neurological Surgery at Weill Cornell Medical College-New York Presbyterian Hospital. He is also an Adjunct Faculty at The Rockefeller University and in the Department of Biomedical Engineering of Cornell University. He graduated Magna Cum Lauda in Molecular Biology and also received a Certificate of Proficiency in Russian Studies Princeton University. He then completed a PhD in Molecular Neurobiology at The Rockefeller University in 1993 and an MD from Cornell University Medical College in 1995. After his neurosurgery residency at the New York Presbyterian Hospital, he completed a fellowship in Stereotactic and Functional Neurosurgery at the University of Toronto. He is an internationally known expert in gene therapy and functional neurosurgery. In 1994, he described the first use of adeno-associated virus (AAV) in the mammalian brain and in 2003 he performed the first human gene therapy procedure for Parkinson’s disease which led to the first randomized, blinded study to show success for a CNS gene therapy. He has also been a lead or key investigator in several other gene therapy trials and studies of neurological devices for degenerative disorders. He has also become a leader in application of non-invasive MR guided focused ultrasound to the brain, including both lesioning of brain targets to improve movement disorders and disruption of the blood-brain barrier to allow non-invasive, focal delivery of biological agents to brain targets affected by neurological disease without surgery. His laboratory continues to focus upon use of both gene therapies and ultrasound technologies to better understand and potentially address unmet needs in Parkinson’s disease, memory and psychiatric disorders and brain tumors. He is an elected member of the American Society for Clinical Investigation and the Society for Neurological Surgeons, among other honors and awards. Alex Green, FRCS(SN), MD Alex Green, FRCS(SN), MD > Effects of DBS on Sleep and Arousal and potential new therapies Alexander L Green is a Neurosurgeon and the Spalding Associate Professor at the University of Oxford. His research focusses on autonomic neuromodulation and more recently, sleep and arousal. He has over 220 peer-reviewed publications and has received a number of prizes including the Congress of Neurological Surgeons (CNS) ‘Stereotactic and Functional Neurosurgery Resident Award’, the ‘Gordon Holmes Prize’ (Royal Society of Medicine), and the International Neuromodulation Society (INS) ‘New Investigator Award’ Jocelyne Bloch, MD Jocelyne Bloch, MD > NEUROTECHNOLOGIES RESTORING MOTOR CONTROL AFTER PARALYSIS Jocelyne Bloch specialized in stereotactic and functional neurosurgery, and acquired an extensive experience in deep brain stimulation (DBS) and neuromodulation for movement disorders, pain and epilepsy. She is in charge of the functional neurosurgical unit at the CHUV. Very active in experimental medicine and translational neuroscience, she nourishes a profound interest in the development of new indications for DBS, and in advancing technologies and therapeutic paradigms in neuromodulation, neuroregeneration, and cell therapy. She seeks to gather all these novel therapeutic strategies under a common umbrella that will foster optimization of treatment options for patients suffering from neurological impairments. Since 2019, she is director of the Defitech Center for Interventional Neurotherapies (NeuroRestore). NeuroRestore is a research,

Speaker Jason M. Schwalb, MD, FAANS, FACSSurgical Director, Movement Disorder & Comprehensive Epilepsy CentersHenry Ford Medical GroupClinical Professor of NeurosurgeryWayne State University,Michigan, USA  > Normal Pressure Hydrocephalus: Management Paradigms and Controversies Individuals with Motor Complete Spinal Cord InjuryNormal Pressure Hydrocephalus (NPH) has been touted as one of the few potentially curable causes of dementia. However, there is significant controversy about whether or not NPH even exists due to the heterogeneity in outcomes. This heterogeneity may be due to patient selection and heuristic errors rather than differences in surgical technique. This talk will address best practices in patient selection, subsequent management and future directions in the field. /wp-content/uploads/videos/wssfn27032021.mp4 Moderated by Dr. A. RUSHNAClinical Instructor, Michigan State UniversityDirector of Restorative and Functional NeurosurgerySpectrum Health Medical GroupGrand Rapids, MI, USA

Speakers Marc SindouEmeritus Professor of Neurosurgery University of Lyon, France > From Imaging to SurgeryThis presentation will expose the selection of patients with classical trigeminal neuralgia for MVD based on clinical and imaging data. Technical nuances in order to avoid complications will be presented on the basis of current evidence including long term outcome. Alternatives to MVD and decision-making algorithms will be addressed for a comprehensive discussion on the surgical treatment of trigeminal neuralgia. Andrei BrinzeuAssociate Professor of Neurosurgery University of Medicine and Pharmacy “Victor Babes” Timisoara, Romania > Reliability of ImagingThis presentation will focus on the reliability of preoperative MRI to identify a neurovascular conflict from a surgical decision-making perspective. Other anatomical abnormalities impacting on surgical indication and outcome will also be presented: angulation of root on crossing over the upper petrous ridge, sagging structures in the posterior fossa, small cerebello-pontine angle cistern, arachnoiditis. /wp-content/uploads/videos/wssfn19122020.mp4 Moderated by Dr Nico EnslinConsultant neurosurgeonRed Cross War Memorial Children’s Hospital and ConstantiabergUniversity of Cape Town, Cape Town, South Africa